Pattern of extrapyramidal signs in Alzheimer’s disease

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

Extrapyramidal signs in cognitively intact elderly people.

AIM to investigate the prevalence of extrapyramidal signs in elderly people and their relationship to disease. SETTING AND SUBJECTS 151 non-demented subjects age 65 and over living within a defined geographical area in Nottingham who were participating in the MRC multicentre Cognitive Function and Ageing Study. MEASUREMENTS subjects were assessed at home. Extrapyramidal signs were rated acc...

Extrapyramidal motor signs in degenerative ataxias.

BACKGROUND Extrapyramidal motor signs (EPS) are well-known symptoms of degenerative ataxia. However, little is known about frequency and appearance of EPS in subtypes of ataxia. METHODS We characterized 311 patients with ataxia clinically and genetically. Course of the disease and EPS were investigated according to a standardized protocol. Diagnostic and prognostic impact of EPS in subtypes o...

Effect of extrapyramidal signs and Lewy bodies on survival in patients with Alzheimer disease.

BACKGROUND Patients with Alzheimer disease (AD) who have psychiatric and parkinsonian symptoms experience faster cognitive deterioration and shorter survival vs those without such disease features. Extrapyramidal signs (EPSs) in particular have been associated with the presence of Lewy bodies (LBs) on autopsy and with poorer survival in patients with AD. Lewy bodies found at autopsy are not alw...

Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates.

BACKGROUND Extrapyramidal signs (EPS) are frequent in Alzheimer's disease (AD) and core manifestation of related diseases, i.e., dementia with Lewy bodies and Parkinson's disease; furthermore, Lewy bodies and AD-type pathology occur in all three conditions. OBJECTIVE To identify clusters of EPS progression over time and their clinical and neuropathological correlates. METHODS 3,502 AD patie...